Better acceleration?

Dale Davies said

A well built and tuned 225 should perform well and get good fuel economy.

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Depends what the individual considers performing well ? Most people hopping up a streetable NA /6 is gonna get around modern NA 4 cylinder power levels of 140-180 net hp not modern 6 cylinder hp if that not enough some kind of power adder or bigger engine is needed.

To me a /6 is more on par with a 4 cyl.
/6 has size compared most 4 cyl so 1000-3000 rpm gonna be stronger even though torques ability to create hp is dramatically reduced at lower rpms eg.. 25% @ 1313 rpm 50% @ 2626 rpm compared to 100%+ from 5252 rpm and up. Most modern 4 cyl have better head flow especially with 4 valves per cyl but /6 does have 6 sets of ports to help make up the difference and most 4 cyl now have variable cams but /6 size will allow a larger cam as a compromise.