aluminum rods vs. titanium rods: fatigue life

Oh my goodness! That's cool! Looks like a Volkswagen engine!
Yes, most are powered by a 1/2 vw engine. They take a Type II flat four and cut off the back two cylinders.
There are some purpose built 2 cyl. engines, Mosler and Global, (out of production but, still available here and there) that are of the same configuration.
The Global uses a forged SCAT crank, forged rods. I think a Chevy 350 con. rod will work, also. VW titanium and aluminum rods are available off the shelf, last I checked. Which was several years ago.