When you add up the additional height of the 4500 carb (4150 is shorter), raised/extended intake ports and a reversion spacer/nitrous plate/etc. You run out of room under a 6 pack, hemi or 023 scoop. A 6" scoop is no problem depending in the intake/spacers/etc.
For instance, the early 70s DC tunnel ram scoop does not come close to clearing our 511" Indy -13 low deck that has an Indy t-ram (4500) topped with QF 1050-AN carbs using HVH adapters with no filter or velocity stack. You run out of hood/scoop clearance quickly with all of these hotrod parts. I design my jnduction systems with a 14x4" filter minimum with 1.5" drop base max. So far no strange issued with AFR readings which leads me to believe the fuel curve is stable.