Edelbrock heads with OEM manifolds

Mine were cars for my daughters in the desert. I wanted no chance of detonation and cooler running. The Edelbrock and Toth heads both did wonders for that.
Sounds awesome except, you want no chance of detonation?
What cam, compression, and timing are you running?
Why would an iron head have this over a aluminum head?
I get the outdoor heat factor of where you live.