EFI

In general, what kind of changes do you usually make? I’m familiar with the Holley software but not the MS stuff. Do you make changes based on weather or the last time slip.
I usually make small adjustments to the VE Table. The Megasquirt data log viewer has a "VE Analyze" feature that will take the data in parameters you set and adjust it to help it reach your target AFR. I use this a lot, its quick and easy. Sometimes it needs a little smoothing out but usually its suggestions are very good. Then when the car is running I allow it to make a certain % of change to help reach the target if for some reason the tune isn't spot on.

I seldom to any manual tuning, if I am working directly on the VE table it is for smoothing adjustments or a flat spot. The tools the log program has can really nail things down. It can also adjust the table live with the laptop plugged in but I only use that if I make some big change. Its a quick way to point things in the right direction.

I like megasquirt, its dollar per feature is amazing. However I think Holley has huge advantages in the software and self learning department. I thought I had a problem that would require replacing my ECU. I priced a dominator out which is what I would need to match my features. Just the ECU with no wiring or anything cost way way more than my entire electronics package.