Fall drive from PA to Maryland? Why yes there are non- Interstate routes for that.

RT 50 across WV is a nice drive, especially going east from I79 two lane road.
If you go West from I79 its a 4 lane road.
Super nice scenery nice drive in any vehicle.
Yes I have been on the 4 lane section from Marietta OH, to I-79 .... Bridgeport area if my memory is correct without looking at the map.

I drove WV 20 from Quiet Dell to US 460 one time... that is a great ride too.

Thanks for the tip.. I will hafta try all of US 50 / 48 / 33 in WV some day!