273 Intake 4 bbl Conversion

So I have an opportunity to buy a 4 barrel intake, and the seller states that it's for 318, 340, and 360 ci V8's. Can this also be used on a 273? Also, what is the 'go-to' 4 barrel carb for the 273? And are there any linkage issues and/or challenges? Any other considerations if making the swap?

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You have a lot of questions there and some variables with our answers.
The intake will work on a 273 as long as the heads are 66 and newer. 64 and 65 heads had smaller bolts and they were at a odd angle. the early heads has 5/16" bolts where the 66 and newer were 3/8". The mis match between larger ports and the smaller 273/318 ports isn't a real issue.
The go to carb size is 500-650 cfm. With a original 2 barrel engine I would find one on the smaller size. Depending on the carb you use and whether your car is a auto or manual transmission, there will be throttle linkage issues and transmission kickdown linkage issues you will need to address.