Are you a Mopar purist?

Back around 1988, my brother had a really solid 66 F100 shortbed, 6 cylinder 3 on the tree. The six cylinder gave up the ghost one Friday night. He drove it to work Monday morning with a 360 4bbl and 727. Literally bolted it in using A body mounts, drilled a few holes in the trans crossmember, and hunted through a pile of driveshafts until he found the right one. Hardest thing was wiring the Chrysler electronic ignition, because Ford used a resistor wire that caused him some issues until he found it out.

Personally, I'd stuff a Mopar drivetrain in anything that isn't a nice survivor or big money car in original condition