Those Running 3.73 And a TF w/ LockUp.. What's your highway Driving Like?

I have 3.73 gears in my '47' Canopy. I'm running a 46rh behind a 340 and I cruise at 60 mph all day and the RPM is 2000. My tire diameter is 27". The only problem I see is very little torque at that rpm so it takes a little more throttle when going uphill. The gas mileage isn't that great. I thought it would improve when I replaced the 727, but it actually went down. If I was you, I would jump to 3.92's, but do the calculations using your tire diameter to see what your RPM's will be. Use the calculator given 'DANTRA' above to get your engine speed.
Some of the responses on this thread recommend going to 3.32 or 2.76. Do the calculations. When I put me 46RH in, I was running 3.55 gears and at 60 mph I was only running 1800 rpm. I don't care what v8 you're using, none of them have any torque at that rpm unless you are running with a very small cam and a very light car. The engine has to have a decent amount of torque to keep the vehicle moving into a headwind. I know because my truck is like a 4/4 piece of plywood pushing air down the road. By the way my mileage with the 727 and 3.55 gears was 15 on the road. The mileage with 46RH and 3.55 gears was 13. Go figure. I think it's because of the low RPM's and less torque. I don't have enough mileage on the 3.73 ears to give an estimation yet. I just put the 3.73 gears in last fall.

Lots of factors involved... You mention running a 340, those tend to have less grunt than 360s. I'm wondering if you're getting into the power enrichment opening the throttle that much when it's in 4th, might be better off downshifting to 3rd when you need any extra acceleration. I know the stock-cammed 360 in my D200 makes peak torque not much over 2000 RPM and would probably work well cruising at 1800; it currently spins at 2800 around 75 mph with a 727, 3.55 gears and 33" tires... I think it would be a good candidate for a 46RH. The Magnum engines that were in front of the RH/RE transmissions from the factory had gobs of torque right off idle so unless your engine is a stump-puller it would probably want higher cruising RPMs.