Camshafts and Compression

Cam grinders can't take into account all the variables involved in the cylinder that affect the burn. They are only guessing at best.

Different fuels have different distillation temps so how can a cam grinder know where exactly to close the valve to best suit what you're using?
The cam grinder can only be as good as the information they’ve been given. If you have a cam ground, and you make more power, or get better driveability, or get better mileage, or whatever you’re after by moving the cam 10 degrees, then you’re giving it up somewhere else. And a different grind will likely (not always) give you better results.