Cam Upgrade for my 408. Need some advice.

I am also building my whip as a hot street setup, that I could occasionally make a pass or two at a real racetrack.

I have manual 4wheel disc brakes, no a/c and heater has been deleted too.

Most of the aftermarket systems are throttle body injection, I prefer individual injectors for each cylinder. I chose the proflo 4. But if it doesn’t pan out, a carb setup will have to work.

From what I have seen the EFI systems are more sensitive to vacuum signal throughout the whole rpm range. Usually the efi is just a little bit less on the HP numbers, but adds a huge benefit with low maintenance and less trouble if the car sits for a while between cruises.
The fact that NASCAR, IMSA, NHRA ProMods and F1 are using EFI shows it can be done.

The tuning is the key. Most people can't justify the cost and time to get a car that can drive in traffic, if they are only running it in the 1/4 mile.