Thank you again for taking the time to explain this to me. I am digesting your response as well as others here. So I actually I AM running a colder 160° thermostat. I had thought bringing the temp down would help alleviate detonation. I get what your saying about colder temps making atomization more difficult. I will try a 190° T- Stat as well as what ever else I can try mechanically. I will also post my timing map.
I suppose I cannot retrofit annular boosters to a 4150 style Holley?
Here’s what the ceramic looks like on my Autolite 65.
View attachment 1716402101