Fan shroud

Even if they're both for a 22" radiator, the slant 6 shroud offsets the fan opening to the opposite side of the radiator than the one for the V8.
In other words, the V8 shroud offsets the fan opening towards the passenger side, the slant 6 opening is offset towards the driver's side. In some cases the slant 6 shroud can be turned upside down and used in a V8 application, but I'm sure there's exceptions to that too. As well as some potential radiator inlet/outlet interference issues, which may require trimming the shroud.