3/4" master cylinder?

The ideal is to aim for 90*, brakes applied. Disc brakes self adjust, so that makes it easy. If using drum brakes, the self adjusters should be used & that will maintain a uniform pedal position.

A few degrees either side of 90* is ok, but aim for 90*. It will NOT wear out the seals because [a] the seals are fitted to the pistons which are a tight fit in the bore, & the pistons do the locating, not the seals the seals are made of soft COMPLIANT rubber to conform to shape changes.
If you have too much angle to the pushrod it will push the piston against the bore and wear that out, hence why I mentioned not more than 3 deg deviation. Once the bore is rough or out of round, its basically over, its going to leak.