Rear Main Seal Offset or Not and rtv usage

Offset dude, all the way. Only has to be enough to ensure the seal parting line is not parallel to the block and rear main cap parting line.

Superformance #9340 Rear Main Seal

The factory never offset the rear main seal and they produced millions of engines that made it through warranty without leaking.
Warranty period is generally about 1/3 of the intended service life of factory parts so that's not really saying much.

Rear main leaks usually happen because of A) improper installation, B) imperfect mating surface or C) letting the car sit for long periods of time. Sitting is especially problematic with a rope seal because they wick oil over time and swell.