Slant six single, to slant six double.
Once you get into machining and cams, you're also into a ton of money.
I had the best luck with a stock cast iron 2 barrel manifold and a 2 barrel carb from a 318. Peppy and on the cheap. Slightly improved mpg and way more responsive throttle.
Machining is nice but it's expensive and these days good machine shops are rare so they can charge what they want.
I have seen quite a few 2 barrel setups come up for sure.