W2/W5/R3 Engine Build Opinions Needed

I am at a fork in the road re: choosing what kind of motor I am going to be building for a mostly strip/little street '35 Plymouth coupe. I know that cost is going to be a little higher on two of the combinations vs the other but the peace of mind of having a more solid bottom end is very comforting.

Both motors will be stroked (steel crank, H-beams, etc.) and running rollers w/ approx. 10.8-11:1. Looking at several cam profiles, TBD.

Motor #1: 48 degree non-siamese R block with cast iron W2 48 degree heads (w/Shady Dell Stage III port work).

Motor #2: 59 degree non-siamese R3 block with aluminum W5 59 degree heads (w/Shady Dell CNC port work).

Motor #3: 59 degree OEM 340/360 block (partially filled) with W5 59 degree heads (w/Shady Dell CNC port work).

Of course, the 48 degree setup will be the most costly of all three with the 59 degree R3/W5 right behind it and the OEM 340/360/W5 combo bringing up the rear.

Again, I am just looking for opinions and feel free to play devil's advocate. It all helps with the process.

TIA