the xe268h is one of those magic cams.. dunno how it works, but it does.. even with low CR engines.
eg: i toss a xe268h cam in a bone stock 400 72 Satellite once, and just like that went from 14.8s to 14.0s w/ the stock 3.55 gear.
i have never seen a 600 or 650 holley make more power then a well tuned holley 750vs carb on a 340/360/. throttle response remained excellent.
i agree with you that tube diameter plays a role in effective rpm use, but equally (perhaps more) important is the collector length.