how much difference between 3.91 and 4.10

well i have 3.23's now and i definatly want as much gear as i can without being massive overkill on the highway...i dont drive the highway that much, and usually if i do its for a half an hour at total maximum....however, i do envision wanting to take my scamp to my aunts place in wasaga which is about 1 and half hours away all highway from where i am...does the fourspeed in your dart sport make a difference rpm wise on the highway?