That's interesting because when reading "Chrysler Engines: 1922-1998" by Bill Weertman he has a chapter about the old V-16 WWII aircraft engine. The engine ended up having only around 6:1 compression but ran over 33 lbs. of boost from the in-line turbocharger + supercharger. I think you'll overall make more HP doing it that way but you definitely won't make much power below the speed where the boost kicks in.
