Help, my exhaust is killing me.

what do the plugs look like. somethings amiss. tuned correctly you can run open headers on the street. you need an air fuel ratio reading.what size carb and what size motor? give us something to work with.could be a bad wire and 1 cyl. not firing.

I will admit I am not an expert with plugs, and they have not been out recently, but I did change them twice in an effort to eliminate fouled plugs, and out of desperation.
Both times the plugs look good, clean, not black or burnt out.
I'll check the plugs again tomorrow.

383 with a Weiand intake, not a highrise, and a 750 Holley. I rebuilt the Holley last year, and I tried to tune it again today for a few hours with the help of a few friends.
Pulled the screws for the bowls, the fuel is up to that level. The mixture screws are out about a turn and a half, anything less and it will not stay running. I can get away with the rears out only a full turn.

Last year I replaced the ignition with an Accel unit, new coil, new wires.

It has been like this throughout this whole process of replacing this, and getting a new that.

I have a horrible taste in my mouth still from driving it today- this is not good.