750 Eddy on 318?

I am building my Duster up. It is a bone stock, all the way to the exhaust 318.

It is my intention to build a 360 over this coming winter where I think I could use the carb.

Currently I would like to use the 750 on my bone stock 318. It would be mounted on a Holley Street Dominator. It will have a set of headers with a large exhaust in preparation for next year. The only other thing is a set of gears most likely.

Is it possible to run the 750 on the Duster with the 318? What is the likely outcome as far as drivability, fuel mileage and performance?

Thank you for your help as always, ROB