Holley Idle mixture screws non responsive?

And thats all I have read as well.. so I originally set my timing at 16 plus the vacuum and mech advance was getting me all in around 38. Still my mixture screws were useless so that is when I started messing with the timing to try to get some response from the screws. I will lock it in again tonight and see if I can check the transition slots.. maybe open the secondaries if need be.