Holley Idle mixture screws non responsive?

ok so now I am really confused, I just went out and checked out my timing. I disconnected the vacuum advance and set it at 16*, I then moved up the rpms to about 2500 and the mechanical advance was all in and was a total of 45*. It is suppose to be a total of 24 advance plus my 16 would be 40* but I guess it's a little off. Anyway, I opened the secondaries a little so I could close the primaries some.. but never the less still no response from the mixture screws.

So what the heck do I do now?