Compression

It depends on how big your cam is as longer duration and wider lobe centers bleed off cylinder pressure. There's a good dynamic compression ratio calculator on the KB website. You will need to know your true measured static CR to get an accurate number though. Altitude also plays a part, but I see that's not a factor in PA.

Piston top and chamber finish as well as head material play a part too not to mention quench.

As you can see, there are many varibles in choosing the correct CR for your application and a good engine builder will do this before even sending the block to the machinist. Give us some more info as requested below.

True static comp ratio. Don't forget to include the gasket thickness and bore size plus the amount the piston is below deck in your calculations.
Cam specs.
We already know your chamber size and head material.
Polished pistons and chamber?
Special coatings on the above?
Piston material? Forged, cast or hyperutectic?
Good new radiator?
Carbed or fuel injected?

The pistons are 4.060 bore, J.E. srp pistons, no special coatings, forged, 351 stroke, aluminium Radiator, carb, the piston is out of the deck 0.09, figuring on using a .051 compressed head gasket. cam specs are still open at this point, other than looking @ a solid roller in the 550-575 lift area, but I am not stuck on any profile at this point.
T.J.