Interesting question, Ratio Effects?

Interesting question, Ratio Effects?

I have been having this discussion with my self allot recently, if that counts. :)

Higher driveshaft rpm / lower = adjust final drive ratio in trans to rear end ratio to yield total vehicle speed or same vehicle speed / same engine rpm (assuming same tire diameter)
I have some theories about advantages and disadvantages.. I cannot see how the engine would care though. The mechanical resistance essentially is the same on the engine if the total mechanical leverage calculates out the same given a different approach to reach the same overall gear ratio. I say essentially because in my opinion an overdrive transmission may yield more more load because it is an additional process prior to tailshaft. My opinions..

DadGum_Teen said
After learning a bit more about "hopping up" electric r/c cars, I've seen that two different Pinion and Spur gear combinations, with the exact same final drive ratio can actually have a major difference on the motor temperature and performance during runs.

Well, how does this all come into play in full scaled, gasoline cars? Let me explain my question...

If you had a car with a low rear end ratio but big tires, with an overall ratio of 1:1 (Tire rotates once for every rpm, [just to make it easy] :???:)

And you had another car with a tall rear end ratio, but little tires, with an overall ratio of 1:1 (And do they have a name for this? For the overall ratio after adding every factor?)

And can this same rule be applied to matching tall transmission gears to low rear gears, and vise-versa?

Both will cruise simultaneously, but what would the pros and cons be of each? There has to be some kind of performance difference dealing with rolling resistance or torque multiplication of some sort, but I just don't know enough about physics to put all the peices together. Has anyone ever read about or discussed this before?