E85 Street\Strip build??

I am considering building a 408 to run on E85. Could not find too much on this forum, unless I searched wrong. Would like to go with 12 to 1 on the compression??? The engine will have forged crank and H beams, aluminum heads flowing in the 300 cfm range.

I have read lots on the fuel system changes and upgrades.

Words of wisdom are appreciated!