#4448308 heads have any potential?

Higher compression helps push the exhaust out. So yes on the street with lower compression the exhaust would flow much better. But what about race motors with 14 to 1 compression? This is where the older heads ported right can outperform the 308 heads with those too large pushrod holes that blocks the flow.

Remember the bigger the cam and rpms the more a large intake port helps. The 308 intake ports are restricted more than the older heads.

High compression and/or "race engines" would be incredibly foolish to use a head like this. If you're trying to get 280cfm from old iron it better be a labor of love or to fit class rules. Because there's no reason to use them asied from those two.