With that much HP on a stock block, I'd say any little bit helps. I'd love to have used an R block, but with 5 kids, I just don't have money, so I just have to cross my fingers, hope stuff doesn't break, and go with what I can afford and have fun with it instead of having a pile of nice parts in my garage that I can't afford to finish. That being said, here is my 2 cents.
My 422 has a main girdle and main studs. The guy who had it before me ran 9.90s with it, and it looks great. I purchased it from him, checked it all out, and I'm happy with how everything looks. He said before he installed the girdle, even with studs that at that much HP he would get cap walk. The girdle seemed to always help that. He ran an all steel Dart, so it wasn't real light, he was making some serious HP. He never had a problem with the rest of the block on this or any other sb's he built, so he spent a little extra on this one with bushed bores, oiling mods, etc. The block isn't filled, and its completely streetable. I'm tuning it down a little, with home-ported edelbrocks, smaller solid roller, etc, but it should still be fun. I was going with Indy heads, but I don't have the money to finish the engine like that and I honestly just don't need that kind of HP, I only go to the track 1-2 times a year. My 2 cents, if it helps!
Although, I'd feel much more comfortable with some nice beefy aftermarket caps...