The pistons would have to be at zero deck and the heads chambers at 80cc , or smaller if one does not deck the block as even the speedpro slug is .015 in the hole in a factory deck block.
Dwayne Porter built a 500HP 383, it had a stock lift cam ... .450 ... with a lot of duration and the heads had no porting at all , he had to cut valve reliefs in the pistons .