How much power is lost through a 518

Splittin hairs. Put the 518 in it and gear accordingly.

Small blocks 340/360 get about the same mileage it doesn't matter what you do.
If you veer from stock cam into performance cams... the mileage just goes down at a certain point.
15-17mpg.
318, little better .now Slant 6... 40 mpg ,mother f'r, just ask any slant owner. Lol jk