Chap here running a Dart with a 360, eddy heads, air gap etc. Car runs 12.88 at the last run I went two. Don't know what he did, but before that it was in the 13.80's. Really a consistant running car/driver. Races it I guess just about every race. Does not run slicks though. Don't remember the brand, but think it was some of those Mickey street tyres. Anyway, has a 8.25 under it and says he has been running it that way for years. Car has full interior etc. and I didn't see any things done to lighten the car any.
I suppose it really comes down to condition of the rear end. As long as the internals are in good shape and as per spec then I would see no reason why not.
When I looked around the info I was getting was that the 8.25 would handle a healthy small block (think someone even had an article posting somewhere that said 500 hp or some such), but the big caveat was to not use slicks.
I'm sure they will chime in again.
Cheers