Nothing much to it as far as work goes, but you can't use the slant six transmission with a V8, doesn't fit. The mounts on the K-member are different between 6 and 8 cylinder but they sell adapters, at least for the pre-72 cars, not sure about spool-type K-members.
Other than that, it's changing around some wiring, getting a V8 radiator and fan, V8 throttle cable, doing the exhaust and that's it. Your easiest route will be to locate a running V8 and trans combo that is complete. You need to use car manifolds in a car and truck trans linkage won't fit in a car.