I built a mild 422 combo some years ago that was built with the understanding that upgrading the top end later would be possible: 340 + .060 (sonic tested), SRP dished pistons in at zero deck, open chamber 596s ported by me (2.05/1.65, what I would call "stage II" level - bowl work,a little pinch work, estimated around 245-250cfm @ .500"), factory rods, cast crank, hydraulic flat tappet Crane cam (H-302-2), RPM intake, 870 Avenger VS carb, cheap 1 5/8 headers. It wasn't dyno'd but the E body it's in has over 10K miles now, driven distance (NH to Carlisle, PA), pump gas, gets over 17mpg, and runs 12.80s @ 109 in the 1/4 on street tires witha terrible 60'. The car weighs 3800lbs and it runs 3.23s and a 2500 convertor. I'm guessing it's around 450hp and a TON of torque. It's never needed to be upgraded...lol.
IMO - if you are thinking about changing heads later - don't use a flat top piston. Take the hit in static ratio "for now", and cam according to the heads you're running. These engines make power low down. In order to make big power higher up you have to give them stuff to breath - intake side and exh side, and you have to get the ports moving by running a cam that works with them. the MP .528 is a small flat tappet even for a 340 stroke. After lash and valve train angles it's only about .485". Yo uare much better served with something larger - if you want to stay cheap the MP .590 would be a better choice. It's IMO still and antique and you'll want to be very careful about degreeing it, but it's going to make more power than the .528. Remember - the stroke increase is 18%. So a safe way to look at it is everything else has to be 18% bigger. the cam - .485" x 18% is .572... the carb 750cfm x 18% is 885, etc...