ON A 225 SOLID LIFTER engine, you can mill a moderate amount ( I would say about .050-.060) with no problems. If you run a bigger then stock cam,you can mill more without problems. I have run heads milled .125 with a bigger then stock cam, and stock valve train, except for stiffer valve springs.
On a 170 engine, with .100 off the head and a mild cam, I did have to use shorter pushrods.
With a hydraulic cam 225, if you mill more then about .030 you should definatly check the lifter preload.