Remove the transmission. You’re going to have a heck of a time trying to work around it. It’s not worth it.
You’re going to have to put the car up on jack stands and support the ends of the frame rails. You’ll need to level the frame rails, and you’ll probably want to support the rockers too.
Once everything is level and supported you’ll want to take a bunch of measurements. You can use the chassis measurements in the factory shop manual, but you’ll want to know how your car actually measures out with you taking the measurements. If you have a brand new replacement crossmember, use a 3/8” drill to drill out all the spot welds on the old one and remove it. That will leave 3/8” holes in the floor pan, which will help you locate the new crossmember AND allow you to plug weld it with a MIG from the top side, which will make your life A LOT easier. If you have an original crossmember removed from another car you can use a spot weld cutter instead because the replacement crossmember will already have all the holes from the old welds being drilled out. But you’ll still probably want to drill a few all the way through. And welding from the bottom isn’t that fun if you’re up on stands.
Needless to say, measure a lot, tack a few spots, measure again.