For a naturally aspirated build, it’s safe for 500-550hp with main studs before the main webbing in the block becomes a concern. The girdle from hughes or at least millling and strapping the caps is a good idea beyond that but usually there is more at play when to say you need those items than just a horsepower number such as projected rpm, severity of usage, and weight of the vehicle it’s going in. Somewhere along the way to large power, the extra webbing in the blocks that are designed for four bolt mains is necessary. The other add ons can carry you to a point, but become a gamble at best.