I haven't driven my 273 enough yet to measure mpg, but daily drove my 65 Newport 4 dr w/ 383 for years. I got 18 mpg hwy, 13 mpg city. That is with Crane XR700 ignition and Holley Pro-jection TBI w/ O2 sensor. Don't know the gearing, but the motor seems to turn slow at 65 mph (no tach). That car is ~4000 lb, so I hope to do much better in my little Dart, and better that most here. I put in a fairly mild cam (0.422/0.444 lift) w/ Rhoads leak-down lifters. The later should help mileage.
Many ways to hyper-mile. Most are obvious to anyone who bicycles. Every time you use the brakes, you waste energy. The old 70's recommendation to press the accelerator lightly like an egg is under it doesn't match engineering theory. An engine is more efficient at higher throttle, as long as you don't go so far to open the power enrichment valve or squirt the accel pump. Of course, if you accelerate fast from a stop light only to brake hard at the next, that is stupid. In road trips in my T&C 3.8L, I try to get behind a big truck. It has an instant mileage display, which is fairly accurate. I get 23 mpg alone and 33 mpg following a truck at 60 mph. At that speed, I can follow at a safe distance, though the scenery never changes. Most people just must go faster, which is fine but don't whine about poor mileage.