In the rear I have air shocks and adjustable shackles set to the lowest lift, and up front I haven't made any suspension modifications but the tires would rub when I turned, so I lengthened the fender braces just a little bit so that my tires would clear.
When I install my 3.91 gears, I will be upgrading the leaf springs and shocks, and going back to a non adjustable shackle.