When it comes to making power there's little sense to building anything smaller than a 440, but a long as you know the limitations not everything has to be the king of the streets or make perfect dollar sense. Most engine you can go with semi mild/wild cam, carb, exhaust and 3.23-3.55 gear and be happy with the performance for what it is beyond that you got to start debating if it's worth it.
The biggest problem with a 6 of any kind it has two less intake ports so the rule of thumb of 2 hp per cfm doesn't apply to a /6. You would need 33% more cfm to make the power of a V8. So a 200 cfm V8 port is said to have a 400 hp potential but that's with a lot of Cam and CR to do it with a more street able cam and CR you would need to run 10% or so more cfm. And from the ported flow numbers I've seen a /6 can barely beat stock 318 flow numbers.
The biggest problem with a 6 of any kind it has two less intake ports so the rule of thumb of 2 hp per cfm doesn't apply to a /6. You would need 33% more cfm to make the power of a V8. So a 200 cfm V8 port is said to have a 400 hp potential but that's with a lot of Cam and CR to do it with a more street able cam and CR you would need to run 10% or so more cfm. And from the ported flow numbers I've seen a /6 can barely beat stock 318 flow numbers.