It depends on how the shifter is made. The brand/type of shifter determines whether it enters the trans from the front or rear. The Cheetah shifter cable exits the front but comes in from the rear of the trans. The cable loops around on the upper RH side of the trans then loops in front of the trans cross member, attaches to the large hole on the LH rear of the trans for a straight shot at the shift lever. The cable stays well away of the headers as it makes its loops. It also has bend radii that are well within the capabilities of the cable. Mine is going on 5 years old now with no issues whatsoever.
The Winters shifter was my next choice as it's a rear-exit cable and enters the trans from the rear. The cable would route and loop in front of the trans crossmember very similarly to the Cheetah. I would think the cable would need to be shorter that the standard 5 footer it comes with. But maybe someone on here that has one can chime in since they've "been there, done that."