All of the factory ram air scoops are too short to make ANY kind of significant "boost". Unless you're getting more than about 4" above the level of the hood, you're still going to be in the boundary layer for the airflow going over most cars. Which means you're not going to see any significant velocities inside the scoop. The scoops also do not have enough surface area to really create a significant amount of pressure. If you don't believe me, take a look at any auto racing format. The hood scoops that are used are huge, and are elevated significantly over the level of the hood. Most of the cold air induction systems in racing are set up to take air from ducts in the nose of the car (where the air is coming straight in), or from somewhere other than the surface of the hood.
They do provide for cooler air into the engine. With proper tuning, this will make more power, and use more fuel if you're taking advantage of the cooler air by upping the fuel. But, the cooler air also should improve the thermal efficiency of the engine. Whether or not that saves you any fuel would depend on the specific temperature of the air, temperature of the engine, atmospheric pressure and air density, all at a given time, and are some pretty involved equations if you really want to get into it.
As far as the vacuum advance being significantly altered, in a word, unlikely. And of course, you're assuming that your vacuum advance and timing are already dialed in to be perfect for maximum fuel mileage. But if you really think you're onto something no one else here understands, you don't need some fancy computer or ignition module. Just hook up a plain old vacuum gauge and drive down the road at 60 mph with a nice steady throttle, once with the ram air open, once with it closed. Taa-daa. If they're significantly different, you may be able to assume that your vacuum advance is ever so slightly different. And if you've really got a lot of time on your hands, you could try more speed variations to figure out EXACTLY where the best/worst mileage occurs. Or, at least, where you think it occurs, since vacuum is only one variable out of a whole ton of variables that effect fuel mileage.