A vacuum secondary, or adjustable air-door, 4bbl carb is just two 2bbl carbs on the same baseplate. You the tuner get to decide When and How-fast to open the second 2bbl. Most of us I would think, have had TQs on stockish teeners, to teeners with X-heads and big-port intakes, at one time or another,and often with crazy hiway gears; and it was never a big deal to get the carb tuned. So, IMO, I wouldn't worry about carb size when selecting a cam.
But,I would worry most about sliding a too-big-for the-combo cam in there. But you're getting a good handle on that by now. And even then, a wrong cam is only about a $300dollar mistake, right? No biggie to rip it out. I did it twice; third time was the charm,lol.
A streeter with a Double-pumper is more for showing off than anything else. And works best with a snappy high-compression engine,a higher stall or manual trans,and bigger rear gears. I really like the 750DP, and the TQ is a close second.
I ran the big TQ on a stock teener, and a 2bbl on a 340 with a teener top-end and cam, and a 4bbl teener with a 340 topend and cam.
I had a blast with the 2bbl hi-compression 340. That used to be my favorite all-time combo.
I also had a blast with the TQ equipped stock teener with 2.76s and a 2800TC.
But the low-C teener with the 340 top,and 2.76s was the laziest POS combo I ever screwed together.This same engine was later resurrected with the teener stuff back on it, the smaller TQ, the 2800TC, headers, and with a either; a 904,a 998,or an A833. I have run it with all kinds of rear gears, depending on my mood, and it has been a fun little engine.