It was totally a theoretical question. I was thought maybe a smaller stroke would give you better fuel economy on day to day driving and then when you'd want to really have fun you'd crank it up to 6000+ hp if needed be (possibly adding a turbo to work on the higher end). But if it makes a difference, I've currently got a 273 that has low compression in one cylinder (may need some head work if I didn't destroy anything else, yet), a 904 transmission that seems to be fine, and a 7 1/4 rear end with open 2.94 gears.
This summer, my plan is to build up my 8 3/4 in the garage (Dr. Diff, bbp, new carrier with an Eaton TrueTrac, bearings, etc.), install bbp discs on all four corners, and install my Hotchkis TVS. However, this will make my engine the weakest link and most likely to blow up first.